Synthesis of Ferrocene Derivatives with Planar Chirality via Palladium-Catalyzed Enantioselective C鈥揌 Bond Activation

详细信息    查看全文

• 作者：Chao Pi ; Xiuling Cui ; Xiuyan Liu ; Mengxing Guo ; Hanyu Zhang ; Yangjie Wu
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：October 3, 2014
• 年：2014
• 卷：16
• 期：19
• 页码：5164-5167
• 全文大小：360K
• ISSN：1523-7052

文摘

The first catalytic and enantioselective C鈥揌 direct acylation of ferrocene derivatives has been developed. A series of 2-acyl-1-dimethylaminomethylferrocenes with planar chirality were provided under highly efficient and concise one-pot conditions with up to 85% yield and 98% ee. The products obtained could be easily converted to various chiral ligands via diverse transformations.