A Cascade of Acid-Promoted C鈥揙 Bond Cleavage and Redox Reactions: From Oxa-Bridged Benzazepines to Benzazepinones

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• 作者：Yuewei Zhang ; Fengzhi Yang ; Lianyou Zheng ; Qun Dang ; Xu Bai
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：December 5, 2014
• 年：2014
• 卷：16
• 期：23
• 页码：6041-6043
• 全文大小：267K
• ISSN：1523-7052

文摘

A sequence of C鈥揙 bond cleavage and redox reactions in oxa-bridged azepines was realized under acid promoted conditions. This protocol provides an atom-economical and straightforward approach to access benzo[b]azepin-5(2H)-ones in high yields. The formal synthesis of tolvaptan was achieved by exploiting this new transformation.