Synthesis of Highly Substituted Imidazolidine-2,4-dione (Hydantoin) through Tf2O-Mediated Dual Activation of Boc-Protected Dipeptidyl Compounds

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• 作者：Hui Liu ; Zhimin Yang ; Zhengying Pan
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：November 21, 2014
• 年：2014
• 卷：16
• 期：22
• 页码：5902-5905
• 全文大小：393K
• ISSN：1523-7052

文摘

Highly substituted chiral hydantoins were readily synthesized from simple dipeptides in a single step under mild conditions. This reaction proceeded through the dual activation of an amide and a tert-butyloxycarbonyl (Boc) protecting group by Tf₂O-pyridine. This method was successfully applied in the preparation of a variety of biologically active compounds, including drug analogs and natural products.