Synthesis of Polysubstituted Pyrazoles by a Platinum-Catalyzed Sigmatropic Rearrangement/Cyclization Cascade

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• 作者：Jia-Jie Wen ; Hai-Tao Tang ; Kai Xiong ; Zong-Cang Ding ; Zhuang-Ping Zhan
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：November 21, 2014
• 年：2014
• 卷：16
• 期：22
• 页码：5940-5943
• 全文大小：361K
• ISSN：1523-7052

文摘

A highly efficient Pt-catalyzed [3,3] sigmatropic rearrangement/cyclization cascade of N-propargylhydrazones is reported. The process provides expedient access to a variety of highly functionalized pyrazoles. The substrate has good substituted group compatibility, and the bioactive 3-CF₃ pyrazoles could be synthesized easily with this method.