Oxazinin A, a Pseudodimeric Natural Product of Mixed Biosynthetic Origin from a Filamentous Fungus

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• 作者：Zhenjian Lin ; Michael Koch ; May Hamdy Abdel Aziz ; Rodrigo Galindo-Murillo ; Ma. Diarey Tianero ; Thomas E. Cheatham ; Louis R. Barrows ; Chris A. Reilly ; Eric W. Schmidt
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：September 19, 2014
• 年：2014
• 卷：16
• 期：18
• 页码：4774-4777
• 全文大小：282K
• ISSN：1523-7052

文摘

A racemic, prenylated polyketide dimer, oxazinin A (1), was isolated from a novel filamentous fungus in the class Eurotiomycetes, and its structure was elucidated spectroscopically. The pentacyclic structure of oxazinin A (1) is a unique combination of benzoxazine, isoquinoline, and a pyran ring. Oxazinin A (1) exhibited antimycobacterial activity and modestly antagonized transient receptor potential (TRP) channels.