Visualization of Zn2+ Ions in Live Zebrafish Using a Luminescent Iridium(III) Chemosensor

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• 作者：Dik-Lung Ma ; Hong-Zhang He ; Hai-Jing Zhong ; Sheng Lin ; Daniel Shiu-Hin Chan ; Liang Wang ; Simon Ming-Yuen Lee ; Chung-Hang Leung ; Chun-Yuen Wong
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2014
• 出版时间：August 27, 2014
• 年：2014
• 卷：6
• 期：16
• 页码：14008-14015
• 全文大小：370K
• ISSN：1944-8252

文摘

A novel luminescent cyclometalated iridium(III) complex-based chemosensor (1) bearing a zinc-specific receptor, tris(2-pyridylmethyl)amine, and the 3-phenyl-1H-pyrazole ligand has been designed and synthesized. Upon the addition of Zn²⁺ ions to a solution of iridium(III) complex 1, a pronounced luminescence color change from blue to green can be observed, which may be attributed to the suppression of photoinduced electron transfer upon complexation of complex 1 with Zn²⁺ ions. The interaction of iridium(III) complex 1 with Zn²⁺ ions was investigated by UV鈥搗is absorption titration, emission titration, and ¹H NMR titration. Furthermore, the iridium(III) complex 1 exhibited good selectivity for Zn²⁺ over 13 other common metal ions, including K⁺, Ag⁺, Na⁺, Ni²⁺, Fe³⁺, Hg²⁺, Cd²⁺, Mg²⁺, Ca²⁺, Cu²⁺, Mn²⁺, Co²⁺, and Pb²⁺ ions. The practical application of the iridium(III) complex 1 in visualizing intracellular Zn²⁺ distribution in live zebrafish was also demonstrated.

Keywords:

iridium(III) complex; zinc ion; chemosensor; luminescent