Determination of Solubility of cAMPNa in Water + (Ethanol, Methanol, and Acetone) within 293.15鈥?13.15 K

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• 作者：Pengpeng Yang ; Qingshi Wen ; Jinglan Wu ; Wei Zhuang ; Yuehui Zhang ; Hanjie Ying
• 刊名：Industrial & Engineering Chemistry Research
• 出版年：2014
• 出版时间：July 2, 2014
• 年：2014
• 卷：53
• 期：26
• 页码：10803-10809
• 全文大小：362K
• ISSN：1520-5045

文摘

The solubility of adenosine 3鈥?5鈥?cyclic monophosphate sodium (cAMPNa) in mixed solvents (water+ethanol, water+methanol, and water+acetone) was measured within 293.15鈭?13.15 K under atmospheric pressure. The (CNIBS)/Redlich鈭扠ister model and the modified Apelblat equation were respectively applied to correlate the solubility data to evaluate the effect of the compositional ratio of the organic solvent and the temperature on the solubility in binary solvents, and satisfactory simulation results were obtained. The solubility of cAMPNa was maximal in pure water and markedly diminished at all evaluated temperatures as the mole fraction of the organic solvent in the aqueous mixture increased. The thermodynamic functions for cAMPNa dissolution in the three solvent mixtures were obtained from the solubility data using the van鈥檛 Hoff and Gibbs equations, and the dissolution behavior was discussed. Dissolution of cAMPNa was endothermic and nonspontaneous in all cases, and the enthalpy was the major contributing force to the Gibbs energy.