Indimicins A鈥揈, Bisindole Alkaloids from the Deep-Sea-Derived Streptomyces sp. SCSIO 03032

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• 作者：Wenjun Zhang ; Liang Ma ; Sumei Li ; Zhong Liu ; Yuchan Chen ; Haibo Zhang ; Guangtao Zhang ; Qingbo Zhang ; Xinpeng Tian ; Chengshan Yuan ; Si Zhang ; Weimin Zhang ; Changsheng Zhang
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：August 22, 2014
• 年：2014
• 卷：77
• 期：8
• 页码：1887-1892
• 全文大小：353K
• ISSN：1520-6025

文摘

Five new bisindole alkaloids, indimicins A鈥揈 (1鈥?b>5), bearing a unique 1鈥?3鈥?dimethyl-2鈥?hydroindole moiety, were isolated from the marine-derived Streptomyces sp. SCSIO 03032, along with two new compounds, lynamicins F and G (6 and 7). Their planar structures were elucidated by detailed interpretation of their MS and NMR spectroscopic data, and the absolute configurations were determined by X-ray crystallographic analysis (for 1), comparison of CD spectra (for 2鈥?b>4), and quantum chemical calculations (for 5). Indimicin B (2) exhibited moderate cytotoxic activity toward the MCF-7 cell line.