Cyclic Hexapeptides from the Deep South China Sea-Derived Streptomyces scopuliridis SCSIO ZJ46 Active Against Pathogenic Gram-Positive Bacteria

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• 作者：Yongxiang Song ; Qinglian Li ; Xue Liu ; Yuchan Chen ; Yun Zhang ; Aijun Sun ; Weimin Zhang ; Jingren Zhang ; Jianhua Ju
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：August 22, 2014
• 年：2014
• 卷：77
• 期：8
• 页码：1937-1941
• 全文大小：250K
• ISSN：1520-6025

文摘

Three new cyclohexapeptides, desotamides B鈥揇 (2鈥?b>4), and the known desotamide (1) were isolated from marine microbe Streptomyces scopuliridis SCSIO ZJ46. The sequences and absolute configurations of 2鈥?b>4 were elucidated on the basis of high-resolution spectroscopic data, Marfey鈥檚 method, and chiral-phase HPLC data. Desotamide C (3) contains a unique N-formyl-kynurenine residue, whereas 4 lacks formylation at the same site. Compounds 1 and 2 displayed notable antibacterial activities against strains of Streptococcus pnuemoniae, Staphylococcus aureus, and methicillin-resistant Staphylococcus epidermidis (MRSE), and structure activity relationship studies revealed the indispensability of the Trp component for antibacterial activity within this new scaffold.