Enantioselective Pd-Catalyzed Allylation of Acyclic 伪-Fluorinated Ketones

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• 作者：Wengui Wang ; Haiming Shen ; Xiao-Long Wan ; Qing-Yun Chen ; Yong Guo
• 刊名：Journal of Organic Chemistry
• 出版年：2014
• 出版时间：July 3, 2014
• 年：2014
• 卷：79
• 期：13
• 页码：6347-6353
• 全文大小：338K
• ISSN：1520-6904

文摘

Significant synthetic challenges remain for the asymmetric synthesis of tertiary 伪-fluoro ketones, which are potentially useful molecules for the development of drugs, agrochemicals, and functional materials. Herein, we describe the development of a method for the catalytic enantioselective synthesis of tertiary 伪-fluoro ketones via the Tsuji鈥揟rost reaction of racemic acyclic 伪-fluorinated ketones. Enantioenriched acyclic 伪-cabonyl tertiary fluorides can be produced with the aid of a palladium/phosphinooxazoline catalyst.