PhI(OAc)2-Mediated Intramolecular Oxidative Aryl-Aldehyde Csp2鈥揅sp2 Bond Formation: Metal-Free Synthesis of Acridone Derivatives

详细信息    查看全文

• 作者：Zisheng Zheng ; Longyang Dian ; Yucheng Yuan ; Daisy Zhang-Negrerie ; Yunfei Du ; Kang Zhao
• 刊名：Journal of Organic Chemistry
• 出版年：2014
• 出版时间：August 15, 2014
• 年：2014
• 卷：79
• 期：16
• 页码：7451-7458
• 全文大小：412K
• ISSN：1520-6904

文摘

A metal-free protocol for direct aryl-aldehyde Csp<sup>2sup>鈥揅sp<sup>2sup> bond formation via a PhI(OAc)<sub>2sub>-mediated intramolecular cross-dehydrogenative coupling (CDC) of various 2-(N-arylamino)aldehydes was developed. The novel methodology requires no need of preactivation of the aldehyde group, is applicable to a large variety of functionalized substrates, and most of all provides a convenient approach to the construction of biologically important acridone derivatives.