Palladium-Nanoparticle-Catalyzed 1,7-Palladium Migration Involving C鈥揌 Activation, Followed by Intramolecular Amination: Regioselective Synthesis of N1-Arylbenzotriazoles and an Evaluation of T

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• 作者：Koji Takagi ; Mohammad Al-Amin ; Naoyuki Hoshiya ; Johan Wouters ; Hiroshi Sugimoto ; Yoshitsugu Shiro ; Hayato Fukuda ; Satoshi Shuto ; Mitsuhiro Arisawa
• 刊名：Journal of Organic Chemistry
• 出版年：2014
• 出版时间：July 3, 2014
• 年：2014
• 卷：79
• 期：13
• 页码：6366-6371
• 全文大小：330K
• ISSN：1520-6904

文摘

A sulfur-modified gold-supported palladium material (SAPd) has been developed bearing palladium nanoparticles on its surface. Herein, we report for the first time the use of SAPd to affect a Pd-nanoparticle-catalyzed 1,7-Pd migration reaction for the synthesis of benzotriazoles via C鈥揌 bond activation. The resulting benzotriazoles were evaluated in terms of their inhibitory activity toward indoleamine 2,3-dioxygenase.