One-Pot Oxidation and Rearrangement of Propargylamines and in Situ Pyrazole Synthesis

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• 作者：Jinshan Chen ; Roberta Properzi ; Daniel P. Uccello ; Jennifer A. Young ; Russell G. Dushin ; Jeremy T. Starr
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：August 15, 2014
• 年：2014
• 卷：16
• 期：16
• 页码：4146-4149
• 全文大小：279K
• ISSN：1523-7052

文摘

Reported here are procedures for a one-pot oxidation and rearrangement of propargylamines to synthesize enaminones, with supporting mechanistic studies. Also reported are the extended one-pot syntheses of pyrazoles, including celecoxib and various heterocyclic compounds.