Catalytic Asymmetric Assembly of C3-Monosubstituted Chiral Carbazolones and Concise Formal Synthesis of (鈭?-Aspidofractinine: Application of Enantioselective Pd-Catalyzed Decarboxylative Protonation o

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• 作者：Ruirui Zhao ; Zhongwen Sun ; Mingjie Mo ; Fangzhi Peng ; Zhihui Shao
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：August 15, 2014
• 年：2014
• 卷：16
• 期：16
• 页码：4178-4181
• 全文大小：315K
• ISSN：1523-7052

文摘

The first method for the asymmetric synthesis of C3-monosubstituted chiral carbazolones, structural motifs common in medicinal chemistry, has been achieved using Pd-catalyzed decarboxylative protonation of carbazolones. This methodology has been applied to the first catalytic enantioselective formal synthesis of (鈭?-aspidofractinine with step economy and simplicity.