Peganumine A, a 尾-Carboline Dimer with a New Octacyclic Scaffold from Peganum harmala

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• 作者：Kai-Bo Wang ; Ying-Tong Di ; Yu Bao ; Chun-Mao Yuan ; Gang Chen ; Da-Hong Li ; Jiao Bai ; Hong-Ping He ; Xiao-Jiang Hao ; Yue-Hu Pei ; Yong-Kui Jing ; Zhan-Lin Li ; Hui-Ming Hua
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：August 1, 2014
• 年：2014
• 卷：16
• 期：15
• 页码：4028-4031
• 全文大小：271K
• ISSN：1523-7052

文摘

Peganumine A (1), a new dimeric 尾-carboline alkaloid characterized by a unique 3,9-diazatetracyclo[6.5.2.0^1,9.0^3,8]pentadec-2-one scaffold, was isolated from the seeds of Peganum harmala. The structure including the absolute configuration was determined by spectroscopic data, X-ray crystallography, ECD calculation, and CD exciton chirality approaches. Compound 1 showed moderate cytotoxic activity against MCF-7, PC-3, and HepG2 cells and selective effects on HL-60 cells with an IC₅₀ value of 5.8 渭M.