Flow Synthesis of Biocompatible Fe3O4 Nanoparticles: Insight into the Effects of Residence Time, Fluid Velocity, and Tube Reactor Dimension on Particle Size Distribution

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• 作者：Mingxia Jiao ; Jianfeng Zeng ; Lihong Jing ; Chunyan Liu ; Mingyuan Gao
• 刊名：Chemistry of Materials
• 出版年：2015
• 出版时间：February 24, 2015
• 年：2015
• 卷：27
• 期：4
• 页码：1299-1305
• 全文大小：539K
• ISSN：1520-5002

文摘

PEGylated Fe₃O₄ nanoparticles were prepared through flow synthesis upon the pyrolysis of ferric acetylacetonate (Fe(acac)₃) in anisole at 250 掳C under pressure of 33 bar, in the presence of 伪,蠅-dicarboxyl-terminated polyethylene glycol (HOOC鈥揚EG鈥揅OOH) and oleylamine. In combination with theoretical analysis, the effects of linear velocity, residence time, and reactor dimension on particle size distribution were systematically investigated. In addition, the impact of Ostwald ripening on particle size distribution was also revealed. In particular, the impacts of monomer concentration distributions along both axial and radial directions of the tube reactor on the particle size distribution were carefully investigated. Under optimized conditions, PEGylated Fe₃O₄ nanoparticles with the relative standard deviation of particle size down to 10.6% were thus obtained. The resulting 4.6 nm particles exhibited excellent colloidal stability and high longitudinal relaxivity (r₁) up to 11.1 mM^鈥?路s^鈥?, which manifested the reliability of flow synthesis in preparing PEGylated Fe₃O₄ nanoparticles as contrast agents for magnetic resonance imaging applications.