Cu-Catalyzed Concise Synthesis of Pyridines and 2-(1H)-Pyridones from Acetaldehydes and Simple Nitrogen Donors

详细信息    查看全文

• 作者：Ziyuan Li ; Xiaoqiang Huang ; Feng Chen ; Chun Zhang ; Xiaoyang Wang ; Ning Jiao
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：February 6, 2015
• 年：2015
• 卷：17
• 期：3
• 页码：584-587
• 全文大小：390K
• ISSN：1523-7052

文摘

A highly selective copper-catalyzed concise synthesis of 3,5-diarylpyridine and 2-(1H)-pyridone has been achieved through cascade Chichibabin-type cyclization, C(sp³)鈥揅(sp³) cleavage, and aerobic oxidation. Azide, ceric ammonium nitrate (CAN), and 2-aminopyridine are disclosed as efficient nitrogen donors in this Cu-catalysis using O₂ as the oxidant. Water and molecular oxygen were employed as the oxygen source in the case of oxygenation.