Arthpyrones A鈥揅, Pyridone Alkaloids from a Sponge-Derived Fungus Arthrinium arundinis ZSDS1-F3

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• 作者：Junfeng Wang ; Xiaoyi Wei ; Xiaochu Qin ; Xiuping Lin ; Xuefeng Zhou ; Shengrong Liao ; Bin Yang ; Juan Liu ; Zhengchao Tu ; Yonghong Liu
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：February 6, 2015
• 年：2015
• 卷：17
• 期：3
• 页码：656-659
• 全文大小：278K
• ISSN：1523-7052

文摘

Three new 4-hydroxy-2-pyridone alkaloids, arthpyrones A鈥揅 (1鈥?b>3), were isolated from the sponge-derived fungus Arthrinium arundinis ZSDS1-F3. Their structures were elucidated on the basis of spectroscopic analysis, CD spectra, quantum chemical calculation, and X-ray single-crystal diffraction analysis. Compounds 1 and 2 possessed a 2-pyridone core featured with a decalin moiety linked via a carboxide bridge bearing a novel oxabicyclo[3.3.1]nonane ring system rarely discovered in nature. A possible biosynthetic pathway for them was proposed.