Ligand-Promoted Pd-Catalyzed Oxime Ether Directed C鈥揌 Hydroxylation of Arenes

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• 作者：Yu-Feng Liang ; Xiaoyang Wang ; Yizhi Yuan ; Yujie Liang ; Xinyao Li ; Ning Jiao
• 刊名：ACS Catalysis
• 出版年：2015
• 出版时间：October 2, 2015
• 年：2015
• 卷：5
• 期：10
• 页码：6148-6152
• 全文大小：480K
• ISSN：2155-5435

文摘

An efficient Pd-catalyzed oxime ether directed ortho C鈥揌 hydroxylation of arenes under neutral conditions has been developed. The efficiency of this hydroxylation is significantly improved by a ligand. Oxone, an inexpensive, readily available, and safe reagent, was employed as terminal oxidant and oxygen source. The challenging electron-deficient substrates could also be monohydroxylated in high efficiency. Drug modification with this protocol was also successfully demonstrated.