Relating Intercellular Variability in Nanoparticle Uptake with Biological Consequence: A Quantitative X-ray Fluorescence Study for Radiosensitization of Cells

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• 作者：Tyron Turnbull ; Michael Douglass ; David Paterson ; Eva Bezak ; Benjamin Thierry ; Ivan Kempson
• 刊名：Analytical Chemistry
• 出版年：2015
• 出版时间：November 3, 2015
• 年：2015
• 卷：87
• 期：21
• 页码：10693-10697
• 全文大小：266K
• ISSN：1520-6882

文摘

Internalized gold nanoparticles were quantified in large numbers of individual prostate cancer cells using large area synchrotron X-ray fluorescence microscopy. Cells were also irradiated with a 6 MV linear accelerator to assess the biological consequence of radiosensitization with gold nanoparticles. A large degree of heterogeneity in nanoparticle uptake between cells resulted in influenced biological effect.