Enhanced Intracellular Delivery and Tissue Retention of Nanoparticles by Mussel-Inspired Surface Chemistry

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• 作者：Kai Chen ; Xiaoqiu Xu ; Jiawei Guo ; Xuelin Zhang ; Songling Han ; Ruibing Wang ; Xiaohui Li ; Jianxiang Zhang
• 刊名：Biomacromolecules
• 出版年：2015
• 出版时间：November 9, 2015
• 年：2015
• 卷：16
• 期：11
• 页码：3574-3583
• 全文大小：821K
• ISSN：1526-4602

文摘

Nanomaterials have been broadly studied for intracellular delivery of diverse compounds for diagnosis or therapy. Currently it remains challenging for discovering new biomolecules that can prominently enhance cellular internalization and tissue retention of nanoparticles (NPs). Herein we report for the first time that a mussel-inspired engineering approach may notably promote cellular uptake and tissue retention of NPs. In this strategy, the catechol moiety is covalently anchored onto biodegradable NPs. Thus, fabricated NPs can be more effectively internalized by sensitive and multidrug resistant tumor cells, as well as some normal cells, resulting in remarkably potentiated in vitro activity when an antitumor drug is packaged. Moreover, the newly engineered NPs afford increased tissue retention post local or oral delivery. This biomimetic approach is promising for creating functional nanomaterials for drug delivery, vaccination, and cell therapy.