Capture of Reactive Monophosphine-Ligated Palladium(0) Intermediates by Mass Spectrometry

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• 作者：Qiuling Zheng ; Yong Liu ; Qinghao Chen ; Meihong Hu ; Roy Helmy ; Edward C. Sherer ; Christopher J. Welch ; Hao Chen
• 刊名：Journal of the American Chemical Society
• 出版年：2015
• 出版时间：November 11, 2015
• 年：2015
• 卷：137
• 期：44
• 页码：14035-14038
• 全文大小：314K
• ISSN：1520-5126

文摘

A long-sought-after reactive monophosphine-ligated palladium(0) intermediate, Pd⁰L (L = phosphine ligand), was detected for the first time from the activation of the Buchwald precatalyst with base. The detection was enabled using desorption electrospray ionization mass spectrometry (DESI-MS) in combination with online reaction monitoring. The subsequent oxidative addition of Pd⁰L with aryl halide and C鈥揘 coupling with amine via reductive elimination was also probed using DESI-MS.