纬- and 未-Lactams from the Leaves of Clausena lansium

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• 作者：De-Yang Shen ; Thi Ngan Nguyen ; Shwu-Jen Wu ; Young-Ji Shiao ; Hsin-Yi Hung ; Ping-Chung Kuo ; Daih-Huang Kuo ; Tran Dinh Thang ; Tian-Shung Wu
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：November 25, 2015
• 年：2015
• 卷：78
• 期：11
• 页码：2521-2530
• 全文大小：508K
• ISSN：1520-6025

文摘

Eight new clausenamides, including three 纬-lactams (1鈥?b>3), four 未-lactams (4鈥?b>7), and an amide (8), and seven known lactams, including compounds 9鈥?b>11, which were purified from natural sources for the first time, were characterized from the leaves of Clausena lansium. Their structures were elucidated using spectroscopic methods, and the absolute configurations were determined using electronic circular dichroism and single-crystal X-ray diffraction analyses with Cu K伪 radiation. Compound 2 (50 渭M) protected 22.24% of cortical neurons against A尾_25鈥?5-induced cell death.