Characterization and Biological Evaluation of Diterpenoids from Casearia graveolens

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• 作者：Jing Xu ; Feifei Ji ; Xiaocong Sun ; Xiangrong Cao ; Shen Li ; Yasushi Ohizumi ; Yuanqiang Guo
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：November 25, 2015
• 年：2015
• 卷：78
• 期：11
• 页码：2648-2656
• 全文大小：432K
• ISSN：1520-6025

文摘

Biologically active substances that promote the neurite outgrowth of nerve cells against neuron degeneration may be useful for the treatment of Alzheimer鈥檚 disease. In a continuing search for bioactive compounds from plants, an ethyl acetate-soluble extract of the twigs of Casearia graveolens showed moderate stimulatory activity of neurite outgrowth from PC12 cells. Further investigation to obtain bioactive compounds led to the isolation of 10 new clerodane diterpenoids, graveopenes A鈥揓 (1鈥?b>10). Their structures including absolute configurations were elucidated based on analysis of their NMR spectroscopic data and experimental and calculated ECD spectra. Compounds 3鈥?b>6 and 8 were shown to stimulate NGF-mediated neurite outgrowth from PC12 cells.