Aspertetranones A鈥揇, Putative Meroterpenoids from the Marine Algal-Associated Fungus Aspergillus sp. ZL0-1b14

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• 作者：Yuezhou Wang ; Shuang Qi ; Ying Zhan ; Nanwen Zhang ; An-an Wu ; Fu Gui ; Kai Guo ; Yanru Yang ; Shugeng Cao ; Zhiyu Hu ; Zhonghui Zheng ; Siyang Song ; Qingyan Xu ; Yuemao Shen ; Xianming Deng
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：October 23, 2015
• 年：2015
• 卷：78
• 期：10
• 页码：2405-2410
• 全文大小：400K
• ISSN：1520-6025

文摘

Aspertetranones A鈥揇 (1鈥?b>4), four new highly oxygenated putative rearranged triketide-sesquiterpenoid meroterpenes, were isolated from the marine algal-associated fungus Aspergillus sp. ZL0-1b14. On the basis of a comprehensive spectroscopic analysis, the planar structures of aspertetranones were determined to possess an unusual skeleton in the terpenoid part. The relative and absolute configurations of the aspertetranones were assigned on the basis of NOESY analysis, X-ray crystallography, and circular dichroism spectroscopy. Compounds 1鈥?b>4 were evaluated for anti-inflammatory activity in LPS-stimulated RAW264.7 macrophages. Aspertetranone D exhibited an inhibitory effect against IL-6 production with 69% inhibition at 40 渭M.