Alkaloids from Pandanus amaryllifolius: Isolation and Their Plausible Biosynthetic Formation

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• 作者：Yu-Chi Tsai ; Meng-Lun Yu ; Mohamed El-Shazly ; Ludger Beerhues ; Yuan-Bin Cheng ; Lei-Chin Chen ; Tsong-Long Hwang ; Hui-Fen Chen ; Yu-Ming Chung ; Ming-Feng Hou ; Yang-Chang Wu ; Fang-Rong Chang
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：October 23, 2015
• 年：2015
• 卷：78
• 期：10
• 页码：2346-2354
• 全文大小：414K
• ISSN：1520-6025

文摘

Pandanus amaryllifolius Roxb. (Pandanaceae) is used as a flavor and in folk medicine in Southeast Asia. The ethanolic crude extract of the aerial parts of P. amaryllifolius exhibited antioxidant, antibiofilm, and anti-inflammatory activities in previous studies. In the current investigation, the purification of the ethanolic extract yielded nine new compounds, including N-acetylnorpandamarilactonines A (1) and B (2); pandalizines A (3) and B (4); pandanmenyamine (5); pandamarilactones 2 (6) and 3 (7), and 5(E)-pandamarilactonine-32 (8); and pandalactonine (9). The isolated alkaloids, with either a 纬-alkylidene-伪,尾-unsaturated-纬-lactone or 纬-alkylidene-伪,尾-unsaturated-纬-lactam system, can be classified into five skeletons including norpandamarilactonine, indolizinone, pandanamine, pandamarilactone, and pandamarilactonine. A plausible biosynthetic route toward 1鈥?b>5, 7, and 9 is proposed.