Cobalt-Catalyzed Decarboxylative 2-Benzoylation of Oxazoles and Thiazoles with 伪-Oxocarboxylic Acids

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• 作者：Ke Yang ; Xinyong Chen ; Yuqi Wang ; Wanqing Li ; Adnan A. Kadi ; Hoong-Kun Fun ; Hao Sun ; Yan Zhang ; Guigen Li ; Hongjian Lu
• 刊名：Journal of Organic Chemistry
• 出版年：2015
• 出版时间：November 6, 2015
• 年：2015
• 卷：80
• 期：21
• 页码：11065-11072
• 全文大小：629K
• ISSN：1520-6904

文摘

Cobalt-catalyzed decarboxylative cross-coupling of oxazoles and thiazoles with 伪-oxocarboxylic acids was developed through an sp² C鈥揌 bond functionalization process. This work represents the first example of cobalt-catalyzed decarboxylative C鈥揌 bond functionalization and provides an efficient means of building some important bioactive heteroaryl ketone derivatives.