Preparation and Self-Assembly of Supramolecular Coil鈥揜od鈥揅oil Triblock Copolymer PPO鈥揹sDNA鈥揚PO

详细信息    查看全文

• 作者：Fen Wu ; Yongshun Song ; Zhiyong Zhao ; Shusheng Zhang ; Zhongqiang Yang ; Zhibo Li ; Ming Li ; Qing-Hua Fan ; Dongsheng Liu
• 刊名：Macromolecules
• 出版年：2015
• 出版时间：October 27, 2015
• 年：2015
• 卷：48
• 期：20
• 页码：7550-7556
• 全文大小：368K
• ISSN：1520-5835

文摘

Utilizing precise recognition of DNA and thermal responsiveness of poly(propylene oxide), we prepared a supramolecular coil鈥搑od鈥揷oil triblock copolymer, PPO鈥揹sDNA鈥揚PO, containing a rigid and charged double-stranded DNA segment in the middle and two thermal responsive PPO segments at the ends. The self-assembly process and structures of final assemblies of this copolymer in aqueous phase were studied by DLS, TEM, and cryo-TEM, which show that spherical assemblies with broad range of sizes were formed under different temperatures or triblock copolymer concentrations. Based on the experimental results, the mechanism of the self-assembly of spherical assemblies was further explained by molecular dynamic simulations.