Enantioselective Synthesis of 伪-exo-Methylene 纬-Butyrolactones via Chromium Catalysis

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• 作者：Weiqiang Chen ; Qin Yang ; Tian Zhou ; Qingshan Tian ; Guozhu Zhang
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：November 6, 2015
• 年：2015
• 卷：17
• 期：21
• 页码：5236-5239
• 全文大小：379K
• ISSN：1523-7052

文摘

Enantioenriched 伪-exo-methylene 纬-butyrolactones have been obtained via a two-step sequence consisting of a highly enantioselective chromium-catalyzed carbonyl 2-(alkoxycarbonyl)allylation and lactonization. A variety of functional groups are compatible under the mild reaction conditions. The synthetic utility of this methodology was demonstrated by two short derivatization transformations and the enantioselective synthesis of (+)-methylenolactocin.