Cyclodextrin-Modified Porous Silicon Nanoparticles for Efficient Sustained Drug Delivery and Proliferation Inhibition of Breast Cancer Cells

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• 作者：Alexandra Correia ; Mohammad-Ali Shahbazi ; Ermei M盲kil盲 ; S茅rgio Almeida ; Jarno Salonen ; Jouni Hirvonen ; H茅lder A. Santos
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2015
• 出版时间：October 21, 2015
• 年：2015
• 卷：7
• 期：41
• 页码：23197-23204
• 全文大小：473K
• ISSN：1944-8252

文摘

Over the past decade, the potential of polymeric structures has been investigated to overcome many limitations related to nanosized drug carriers by modulating their toxicity, cellular interactions, stability, and drug-release kinetics. In this study, we have developed a successful nanocomposite consisting of undecylenic acid modified thermally hydrocarbonized porous silicon nanoparticles (UnTHCPSi NPs) loaded with an anticancer drug, sorafenib, and surface-conjugated with heptakis(6-amino-6-deoxy)-尾-cyclodextrin (HABCD) to show the impact of the surface polymeric functionalization on the physical and biological properties of the drug-loaded nanoparticles. Cytocompatibility studies showed that the UnTHCPSi鈥揌ABCD NPs were not toxic to breast cancer cells. HABCD also enhanced the suspensibility and both the colloidal and plasma stabilities of the UnTHCPSi NPs. UnTHCPSi鈥揌ABCD NPs showed a significantly increased interaction with breast cancer cells compared to bare NPs and also sustained the drug release. Furthermore, the sorafenib-loaded UnTHCPSi鈥揌ABCD NPs efficiently inhibited cell proliferation of the breast cancer cells.