Noncovalent Ruthenium(II) Complexes鈥揝ingle-Walled Carbon Nanotube Composites for Bimodal Photothermal and Photodynamic Therapy with Near-Infrared Irradiation

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• 作者：Pingyu Zhang ; Huaiyi Huang ; Juanjuan Huang ; Hongmin Chen ; Jinquan Wang ; Kangqiang Qiu ; Donglei Zhao ; Liangnian Ji ; Hui Chao
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2015
• 出版时间：October 21, 2015
• 年：2015
• 卷：7
• 期：41
• 页码：23278-23290
• 全文大小：727K
• ISSN：1944-8252

文摘

To enhance the efficacy and optimize the treatment of cancers, the integration of multimodal treatment strategies leading to synergistic effects is a promising approach. The coassembly of multifunctional agents for systematic therapies has received considerable interest in cancer treatment. Herein, Ru(II) complex-functionalized single-walled carbon nanotubes (Ru@SWCNTs) are developed as nanotemplates for bimodal photothermal and two-photon photodynamic therapy (PTT-TPPDT). SWCNTs have the ability to load a great amount of Ru(II) complexes (Ru1 or Ru2) via noncovalent 蟺鈥撓€ interactions. The loaded Ru(II) complexes are efficiently released by the photothermal effect of irradiation from an 808 nm diode laser (0.25 W/cm²). The released Ru(II) complexes produce singlet oxygen species (¹O₂) upon two-photon laser irradiation (808 nm, 0.25 W/cm²) and can be used as a two-photon photodynamic therapy (TPPDT) agent. Based on the combination of photothermal therapy and two-photon photodynamic therapy, Ru@SWCNTs have greater anticancer efficacies than either PDT using Ru(II) complexes or PTT using SWCNTs in two-dimensional (2D) cancer cell and three-dimensional (3D) multicellular tumor spheroid (MCTS) models. Furthermore, in vivo tumor ablation is achieved with excellent treatment efficacy under a diode laser (808 nm) irradiation at the power density of 0.25 W/cm² for 5 min. This study examines an efficacious bimodal PTT and TPPDT nanoplat form for the development of cancer therapeutics.