Tungsten Sulfide Quantum Dots as Multifunctional Nanotheranostics for In Vivo Dual-Modal Image-Guided Photothermal/Radiotherapy Synergistic Therapy

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• 作者：Yuan Yong ; Xiaju Cheng ; Tao Bao ; Mian Zu ; Liang Yan ; Wenyan Yin ; Cuicui Ge ; Dongliang Wang ; Zhanjun Gu ; Yuliang Zhao
• 刊名：ACS Nano
• 出版年：2015
• 出版时间：December 22, 2015
• 年：2015
• 卷：9
• 期：12
• 页码：12451-12463
• 全文大小：1061K
• ISSN：1936-086X

文摘

Designing a multifunctional nanomedicine for integration of precise diagnosis and effective treatment of tumors is desirable but remains a great challenge. Here, we report a multifunctional nanomedicine based on WS₂ quantum dots (QDs), which was prepared by a facile and 鈥済reen鈥?method through physical grinding and ultrasonication. The as-obtained WS₂ QDs with small size (3 nm) possess not only significant X-ray computed tomography (CT)/photoaccoustic (PA) imaging signal enhancement but also remarkable photothermal therapy (PTT)/radiotherapy (RT) synergistic effect for tumor treatment. With CT/PA imaging and the synergistic effect between PTT and RT, the tumor could be accurately positioned and thoroughly eradicated in vivo after intravenous injection of WS₂ QDs. Moreover, hematoxylin and eosin staining, blood hematology, and biochemistry analysis revealed no noticeable toxicity of WS₂ QDs in vitro and in vivo, which confirmed that WS₂ QDs possess good biocompatibility. This multifunctional nanoparticle could play an important role in facilitating simultaneously multimodal imaging and synergistic therapy between PTT and RT to achieve better therapeutic efficacy.