Gold over Branched Palladium Nanostructures for Photothermal Cancer Therapy

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• 作者：Andrew J. McGrath ; Yi-Hsin Chien ; Soshan Cheong ; David A. J. Herman ; John Watt ; Anna M. Henning ; Lucy Gloag ; Chen-Sheng Yeh ; Richard D. Tilley
• 刊名：ACS Nano
• 出版年：2015
• 出版时间：December 22, 2015
• 年：2015
• 卷：9
• 期：12
• 页码：12283-12291
• 全文大小：576K
• ISSN：1936-086X

文摘

Bimetallic nanostructures show exciting potential as materials for effective photothermal hyperthermia therapy. We report the seed-mediated synthesis of palladium鈥揼old (Pd鈥揂u) nanostructures containing multiple gold nanocrystals on highly branched palladium seeds. The nanostructures were synthesized via the addition of a gold precursor to a palladium seed solution in the presence of oleylamine, which acts as both a reducing and a stabilizing agent. The interaction and the electronic coupling between gold nanocrystals and between palladium and gold broadened and red-shifted the localized surface plasmon resonance absorption maximum of the gold nanocrystals into the near-infrared region, to give enhanced suitability for photothermal hyperthermia therapy. Pd鈥揂u heterostructures irradiated with an 808 nm laser light caused destruction of HeLa cancer cells in vitro, as well as complete destruction of tumor xenographs in mouse models in vivo for effective photothermal hyperthermia.