Protein Structural Dynamics Revealed by Time-Resolved X-ray Solution Scattering

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• 作者：Jong Goo Kim ; Tae Wu Kim ; Jeongho Kim ; Hyotcherl Ihee
• 刊名：Accounts of Chemical Research
• 出版年：2015
• 出版时间：August 18, 2015
• 年：2015
• 卷：48
• 期：8
• 页码：2200-2208
• 全文大小：623K
• ISSN：1520-4898

文摘

One of the most important questions in biological science is how a protein functions. When a protein performs its function, it undergoes regulated structural transitions. In this regard, to better understand the underlying principle of a protein function, it is desirable to monitor the dynamic evolution of the protein structure in real time. To probe fast and subtle motions of a protein in physiological conditions demands an experimental tool that is not only equipped with superb spatiotemporal resolution but also applicable to samples in solution phase.