Synthesis of Mesoporous Silica/Reduced Graphene Oxide Sandwich-Like Sheets with Enlarged and 鈥淔unneling鈥?Mesochannels

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• 作者：Yupu Liu ; Wei Li ; Dengke Shen ; Chun Wang ; Xiaomin Li ; Manas Pal ; Renyuan Zhang ; Lei Chen ; Chi Yao ; Yong Wei ; Yuhui Li ; Yujuan Zhao ; Hongwei Zhu ; Wenxing Wang ; Ahmed Mohamed El鈭扵oni ; Fan Zhang ; Dongyuan Zhao
• 刊名：Chemistry of Materials
• 出版年：2015
• 出版时间：August 25, 2015
• 年：2015
• 卷：27
• 期：16
• 页码：5577-5586
• 全文大小：514K
• ISSN：1520-5002

文摘

Here, we report the synthesis of reduced graphene oxide@mesoporous silica (denoted as rGO@mSiO₂) sandwich-like sheets by an oil鈥搘ater biphase stratification approach. The resultant rGO@mSiO₂ nanosheets possess a uniform sandwich-like structure, ultrathin thickness (鈭?0 nm), large aspect ratio, high surface area (鈭?55 m²/g), and enlarged and tunable pore size (from 2.8 to 8.9 nm). Significantly, the mesochannels are oriented perpendicularly to graphene surfaces and shaped like a funnel, which facilitates drug loading and releasing. The influences of the concentration of precursor, solvent, GO sheet, and reaction temperature on the formation of the sandwich-like rGO@mSiO₂ nanosheets have been systematically investigated. The resultant nanosheets with a pore size of 鈭?.9 nm show the maximum loading capacity of bovine 尾-lactoglobulin (55.1 wt %). The protein releasing process in the simulated body fluid suggests that the release can be controlled from 20 to 60 h simply by adjusting the pore size. In addition, the degradability of rGO@mSiO₂ nanosheets can be well-controlled by tuning the pore size as well. Most importantly, the nanosheets exhibit a rapid photothermal heating under the near infrared (NIR) irradiation. Therefore, the resultant nanosheets would have a hopeful prospect in a large鈥搈olecule鈥搘eight drug delivery system, which have both the chemical and photothermal therapeutic functions.