Multifunctional Gadolinium-Doped Manganese Carbonate Nanoparticles for Targeted MR/Fluorescence Imaging of Tiny Brain Gliomas

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• 作者：Chen Shao ; Shuai Li ; Wei Gu ; Ningqiang Gong ; Juan Zhang ; Ning Chen ; Xiangyang Shi ; Ling Ye
• 刊名：Analytical Chemistry
• 出版年：2015
• 出版时间：June 16, 2015
• 年：2015
• 卷：87
• 期：12
• 页码：6251-6257
• 全文大小：483K
• ISSN：1520-6882

文摘

Manganese (Mn)-based nanoparticles have been proved to be promising MR T₁ contrast agents for the diagnosis of brain tumors. However, most of them exhibit a low relaxation rate, resulting in an insufficient enhancement effect on tiny gliomas. Herein, we developed gadolinium (Gd)-doped MnCO₃ nanoparticles with a size of 11 nm via the thermal decomposition of Mn-oleate in the presence of Gd-oleate. Owing to the small size and Gd doping, these Gd-doped MnCO₃ NPs, when endowed with excellent aqueous dispersibility and colloidal stability, exhibited a high r₁ relaxivity of 6.81 mM^鈥? s^鈥?. Moreover, the Gd/MnCO₃ NPs were used as a reliable platform to construct a glioma-targeted MR/fluorescence bimodal nanoprobe. The high relaxivity, the bimodal imaging capability, and the specificity nominate the multifunctional Gd doped MnCO₃ NPs as an effective nanoprobe for the diagnostic imaging of tiny brain gliomas with an improved efficacy.