Enantioselective and Synergetic Toxicity of Axial Chiral Herbicide Propisochlor to SP2/0 Myeloma Cells

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• 作者：Yao Liu ; Xuan Zhang ; Chunhong Liu ; Ruili Yang ; Zhenlin Xu ; Lijun Zhou ; Yuanming Sun ; Hongtao Lei
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2015
• 出版时间：September 16, 2015
• 年：2015
• 卷：63
• 期：36
• 页码：7914-7920
• 全文大小：361K
• ISSN：1520-5118

文摘

The axial chiral herbicide propisochlor is used to control weeds. Different enantiomers of a compound usually have different biological activities. It is unclear how the toxicities of the propisochlor enantiomers differ. Propisochlor enantiomers, separated by high-performance liquid chromatography, were tested on SP2/0 myeloma cells. Cytotoxicity and apoptosis were measured, and interactions between the enantiomers were evaluated. The rac-propisochlor, pure R-(+) isomer, and pure S-(鈭? isomer inhibited cell proliferation and induced apoptosis. The rac-propisochlor, R-(+) isomer, and S-(鈭? isomer half maximal effective concentration values after 24 h of incubation were 111 卤 0.15, 68 卤 0.09, and 99 卤 0.21 渭M, respectively. R-(+) isomer induced the most apoptosis. R-(+) isomer was 鈭?.63 times more cytotoxic than rac-propisochlor and 鈭?.46 times more cytotoxic than S-(鈭? isomer. Antagonistic cytotoxic interactions were found between R-(+) and S-(鈭? isomers. This is the first time the toxicities of these enantiomers and antagonism between the enantiomers have been reported. The antagonism indicates that the ecotoxicological effects of the enantiomers should be investigated.