Polyketides with 伪-Glucosidase Inhibitory Activity from a Mangrove Endophytic Fungus, Penicillium sp. HN29-3B1

详细信息    查看全文

• 作者：Yayue Liu ; Qin Yang ; Guoping Xia ; Hongbo Huang ; Hanxiang Li ; Lin Ma ; Yongjun Lu ; Lei He ; Xuekui Xia ; Zhigang She
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：August 28, 2015
• 年：2015
• 卷：78
• 期：8
• 页码：1816-1822
• 全文大小：331K
• ISSN：1520-6025

文摘

Five new compounds, pinazaphilones A and B (1, 2), two phenolic compounds (4, 5), and penicidone D (6), together with the known Sch 1385568 (3), (卤)-penifupyrone (7), 3-O-methylfunicone (8), 5-methylbenzene-1,3-diol (9), and 2,4-dihydroxy-6-methylbenzoic acid (10) were obtained from the culture of the endophytic fungus Penicillium sp. HN29-3B1, which was isolated from a fresh branch of the mangrove plant Cerbera manghas collected from the South China Sea. Their structures were determined by analysis of 1D and 2D NMR and mass spectroscopic data. Structures of compounds 4 and 7 were further confirmed by a single-crystal X-ray diffraction experiment using Cu K伪 radiation. The absolute configurations of compounds 1鈥?b>3 were assigned by quantum chemical calculations of the electronic circular dichroic spectra. Compounds 2, 3, 5, and 7 inhibited 伪-glucosidase with IC₅₀ values of 28.0, 16.6, 2.2, and 14.4 渭M, respectively, and are thus more potent than the positive control, acarbose.