Randainins A鈥揇, Based on Unique Diterpenoid Architectures, from Callicarpa randaiensis

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• 作者：Ho-Hsi Cheng ; Yuan-Bin Cheng ; Tsong-Long Hwang ; Yao-Haur Kuo ; Chung-Hsiung Chen ; Ya-Ching Shen
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：August 28, 2015
• 年：2015
• 卷：78
• 期：8
• 页码：1823-1828
• 全文大小：360K
• ISSN：1520-6025

文摘

Four new compounds, randainins A鈥揇 (1鈥?b>4), were isolated from the leaves and twigs of Callicarpa randaiensis, which is an endemic species in Taiwan. Compounds 1 and 2 are diterpenoids with an unusual trans-7/5 ring system, whereas compounds 3 and 4 are diterpenoids possessing a trans-5/7 ring scaffold. The structures of the new compounds were established based on NMR and MS data analyses. Anti-inflammatory activities and cytotoxicity were tested and evaluated for these compounds. Compound 4 exhibited moderate inhibition of superoxide-anion generation with an IC<sub>50sub> value of 21.5 卤 2.5 渭M.