Divergent Total Syntheses of Rhodomyrtosones A and B

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• 作者：Anais Gervais ; Kiel E. Lazarski ; John A. Porco ; Jr.
• 刊名：Journal of Organic Chemistry
• 出版年：2015
• 出版时间：October 2, 2015
• 年：2015
• 卷：80
• 期：19
• 页码：9584-9591
• 全文大小：469K
• ISSN：1520-6904

文摘

Herein, we report total syntheses of the tetramethyldihydroxanthene natural product rhodomyrtosone B and the related bis-furan 尾-triketone natural product rhodomyrtosone A. Nickel-(II)-catalyzed 1,4-conjugate addition of an 伪-alkylidene-尾-dicarbonyl substrate was developed to access the congener rhodomyrtosone B, and oxygenation of the same monoalkylidene derivative followed by cyclization was employed to obtain the bis-furan natural product rhodomyrtosone A.