Eremophilane Sesquiterpenes and Polyketones Produced by an Endophytic Guignardia Fungus from the Toxic Plant Gelsemium elegans

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• 作者：Yunbao Liu ; Yong Li ; Jing Qu ; Shuanggang Ma ; Caixia Zang ; Yutian Zhang ; Shishan Yu
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：September 25, 2015
• 年：2015
• 卷：78
• 期：9
• 页码：2149-2154
• 全文大小：304K
• ISSN：1520-6025

文摘

A cultured endophytic fungus, Guignardia mangiferae, isolated from the toxic plant Gelsemium elegans yielded five new sesquiterpenes (1鈥?b>5), two new polyketones (6 and 7), and two known terpene polyketones (8 and 9). Their structures were elucidated using spectroscopic methods. On the basis of circular dichroism, the absolute configurations of the new compounds were determined. Compounds 1, 3, 4, and 9 inhibited lipopolysaccharide-induced NO production in BV2 cells with IC₅₀ values of 15.2, 6.4, 4.2, and 4.5 渭M, respectively (positive control curcumin, IC₅₀ = 3.9 渭M).