Nocarbenzoxazoles A鈥揋, Benzoxazoles Produced by Halophilic Nocardiopsis lucentensis DSM 44048

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• 作者：Mingwei Sun ; Xiaomei Zhang ; Huilin Hao ; Wenjun Li ; Chunhua Lu
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：August 28, 2015
• 年：2015
• 卷：78
• 期：8
• 页码：2123-2127
• 全文大小：268K
• ISSN：1520-6025

文摘

Seven new benzoxazole derivatives, nocarbenzoxazoles A鈥揋 (1鈥?b>7), were isolated from the halophilic strain Nocardiopsis lucentensis DSM 44048. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopic data, HRESIMS, and X-ray single-crystal diffraction. The isolated compounds were assayed for their cytotoxicity against a panel of human tumor cell lines (HepG2, MDA-MB-231, MDA-MB-435, HeLa, and PC3). Compounds 1鈥?b>6 were found to have modest or no activity. Compound 7 showed selective activity against HepG2 and HeLa with IC₅₀ values of 3 and 1 渭M, respectively.