Phenolic Compounds from the Leaves and Twigs of Osteomeles schwerinae That Inhibit Rat Lens Aldose Reductase and Vessel Dilation in Zebrafish Larvae

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• 作者：Ik-Soo Lee ; Seung-Hyun Jung ; Yun Mi Lee ; So-Jin Choi ; Hang Sun ; Jin Sook Kim
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：September 25, 2015
• 年：2015
• 卷：78
• 期：9
• 页码：2249-2254
• 全文大小：300K
• ISSN：1520-6025

文摘

Three new phenolic biphenyl derivatives (1鈥?b>3) and one new lignan glycoside (4) were isolated from the leaves and twigs of Osteomeles schwerinae. The structures of the new compounds were established by spectroscopic data interpretation. The inhibitory effects of 1鈥?b>4 on rat lens aldose reductase in vitro were examined, and compounds 1鈥?b>3 markedly inhibited the enzyme with IC₅₀ values of 3.8 to 13.8 渭M. In addition, the effects of these isolates on the dilation of hyaloid-retinal vessels induced by high glucose (HG) in zebrafish larvae were investigated. Compound 1 was the most effective in reducing HG-induced dilation of hyaloid-retinal vessels.