Saccharothrixones A鈥揇, Tetracenomycin-Type Polyketides from the Marine-Derived Actinomycete Saccharothrix sp. 10-10

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• 作者：Maoluo Gan ; Bin Liu ; Yi Tan ; Qiang Wang ; Hongxia Zhou ; Hongwei He ; Yuhui Ping ; Zhaoyong Yang ; Yiguang Wang ; Chunling Xiao
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：September 25, 2015
• 年：2015
• 卷：78
• 期：9
• 页码：2260-2265
• 全文大小：379K
• ISSN：1520-6025

文摘

Saccharothrixones A鈥揅 (1鈥?b>3), three new aromatic polyketide seco-tetracenomycins, and saccharothrixone D (4), a new tetracenomycin analogue possessing opposite configurations at all of the stereogenic centers, were isolated from the marine-derived actinomycete Saccharothrix sp. 10-10. Compounds 1鈥?b>3 represent the first examples of seco-tetracenomycins where the quinone ring B is cleaved and re-formed into a furanone ring. Their structures were elucidated by spectroscopic analyses and ECD calculations. The absolute configuration of 4 was confirmed by single-crystal X-ray diffraction analysis. Saccharothrixone D (4) showed in vitro cytotoxic activity against the HepG2 cancer cell line with an IC₅₀ value of 7.5 渭M.