Anti-inflammatory Labdane Diterpenoids from Leonurus macranthus

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• 作者：Zheng Huang ; Zhi-Xiang Zhu ; Yue-Ting Li ; Dao-Ran Pang ; Jiao Zheng ; Qian Zhang ; Yun-Fang Zhao ; Daneel Ferreira ; Jordan K. Zjawiony ; Peng-Fei Tu ; Jun Li
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：September 25, 2015
• 年：2015
• 卷：78
• 期：9
• 页码：2276-2285
• 全文大小：382K
• ISSN：1520-6025

文摘

Twenty new polyoxygenated labdane diterpenoids (1鈥?b>20) were isolated from the aerial parts of Leonurus macranthus. Their structures were elucidated on the basis of spectroscopic and spectrometric data (1D and 2D NMR, IR, and HRESIMS). The absolute configurations of macranthin A (1) and 6-O-deacetylmacranthin A (2) were determined by single-crystal X-ray crystallographic analysis and a modified Mosher鈥檚 method, respectively. Compounds 1鈥?b>9, 12, 14, and 19 showed inhibition of nitric oxide production in lipopolysaccharide-activated BV-2 microglial cells with IC₅₀ values of 10.0鈥?3.7 渭M.