Bioactive C21 Steroidal Glycosides from the Roots of Cynanchum otophyllum That Suppress the Seizure-like Locomotor Activity of Zebrafish Caused by Pentylenetetrazole

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• 作者：Jin-Long Li ; Juan Zhou ; Zhen-Hua Chen ; Sheng-Ya Guo ; Chun-Qi Li ; Wei-Min Zhao
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：July 24, 2015
• 年：2015
• 卷：78
• 期：7
• 页码：1548-1555
• 全文大小：427K
• ISSN：1520-6025

文摘

Six new C₂₁ steroidal glycosides, cynotophyllosides A鈥揊 (1鈥?b>6), together with 16 known compounds, were isolated from the roots of Cynanchum otophyllum. The structures of the new compounds were elucidated by spectroscopic analysis and chemical methods. The three major components, otophylloside F (15), otophylloside B (17), and rostratamine 3-O-尾-d-oleandropyranosyl-(1鈫?)-尾-d-cymaropyranosyl-(1鈫?)-尾-d-cymaropyranoside (18), suppressed the seizure-like locomotor activity caused by pentylenetetrazole in zebrafish. Preliminary structure鈥揳ctivity relation studies revealed that a pregnene skeleton with a C-12 ester group (ikemaoyl > cinnamoyl > hydroxy > p-hydroxybenzoyl) and a C-3 sugar chain consisting of three 2,6-dideoxysaccharide units is essential for this suppressive activity.