Bioactive Diterpenoids from the Leaves of Callicarpa macrophylla

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• 作者：Jing Xu ; Yihang Sun ; Meicheng Wang ; Quanhui Ren ; Shen Li ; Hao Wang ; Xiaocong Sun ; Da-Qing Jin ; Hongwei Sun ; Yasushi Ohizumi ; Yuanqiang Guo
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：July 24, 2015
• 年：2015
• 卷：78
• 期：7
• 页码：1563-1569
• 全文大小：371K
• ISSN：1520-6025

文摘

A phytochemical investigation of the leaves of Callicarpa macrophylla led to the isolation of five new diterpenoids (1鈥?b>5), macrophypenes A鈥揈, and nine known analogues (6鈥?b>14). The structures of 1鈥?b>5 were established on the basis of extensive analysis of NMR spectroscopic data, X-ray diffraction data, and experimental and calculated electronic circular dichroism spectra. Compound 1 is a spiroditerpenoid with a novel skeleton, and compound 5 is a rare ent-abietane diterpenoid possessing a peroxide bridge. Compounds 1, 5鈥?b>7, and 11鈥?b>14 stimulate nerve growth factor mediated neurite outgrowth from PC12 cells.