Armochaetoglobins A鈥揓: Cytochalasan Alkaloids from Chaetomium globosum TW1-1, a Fungus Derived from the Terrestrial Arthropod Armadillidium vulgare

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• 作者：Chunmei Chen ; Jianping Wang ; Junjun Liu ; Hucheng Zhu ; Bin Sun ; Jing Wang ; Jinwen Zhang ; Zengwei Luo ; Guangmin Yao ; Yongbo Xue ; Yonghui Zhang
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：June 26, 2015
• 年：2015
• 卷：78
• 期：6
• 页码：1193-1201
• 全文大小：402K
• ISSN：1520-6025

文摘

Ten new cytochalasan alkaloids, termed armochaetoglobins A鈥揓 (1鈥?b>10), and four known chaetoglobosins (11鈥?b>14) were isolated from a methanol extract of Chaetomium globosum TW1-1, a fungus isolated from the medicinal terrestrial arthropod Armadillidium vulgare. Their structures were elucidated by a combination of spectroscopy, single-crystal X-ray crystallography, and ECD calculations. Armochaetoglobins A鈥揈 (1鈥?b>5) represented the first examples of seco-chaetoglobosins arising from an oxidative cleavage of C-19 and C-20. Among these compounds, armochaetoglobin A (1) features an unusual pyrrole ring. The cytotoxic activities of 2鈥?b>10 were evaluated, and armochaetoglobin H (8) showed moderate inhibitory activities against five human cancer cell lines, with IC₅₀ values ranging from 3.31 to 9.83 渭M.