Base Mediated Synthesis of Alkyl-aryl Ethers from the Reaction of Aliphatic Alcohols and Unsymmetric Diaryliodonium Salts

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• 作者：Sunil K. Sundalam ; David R. Stuart
• 刊名：Journal of Organic Chemistry
• 出版年：2015
• 出版时间：June 19, 2015
• 年：2015
• 卷：80
• 期：12
• 页码：6456-6466
• 全文大小：591K
• ISSN：1520-6904

文摘

The base mediated coupling of aliphatic alcohol pronucleophiles with unsymmetric diaryliodonium salt electrophiles is described. This metal-free reaction is operationally simple, proceeds at mild temperature, and displays broad substrate scope to generate industrially important alkyl-aryl ethers in moderate to excellent yield. The synthetic utility of these reactions is demonstrated, and aspects of sustainability are highlighted by the use of unsymmetric aryl(mesityl)iodonium arylating reagents.