Tracking Drug Loading Capacities of Calcium Silicate Hydrate Carrier: A Comparative X-ray Absorption Near Edge Structures Study

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• 作者：Xiaoxuan Guo ; Zhiqiang Wang ; Jin Wu ; Yun-Mui Yiu ; Yongfeng Hu ; Ying-Jie Zhu ; Tsun-Kong Sham
• 刊名：Journal of Physical Chemistry B
• 出版年：2015
• 出版时间：August 6, 2015
• 年：2015
• 卷：119
• 期：31
• 页码：10052-10059
• 全文大小：587K
• ISSN：1520-5207

文摘

Mesoporous spheres of calcium silicate hydrate (MS-CSH) have been prepared by an ultrasonic method. Following an earlier work in which we have revealed the interactions between ibuprofen (IBU) and CSH carriers with different morphologies by X-ray absorption near edge structures (XANES) analysis. In the present investigation, two new drug molecules, alendronate sodium (ALN) and gentamicin sulfate (GS), were incorporated into MS-CSH, and their drug loading capacities (DLCs) were measured using thermogravimetric analysis to establish the relationship between drug-carrier interactions and DLCs. The XANES spectra clearly indicate that acidic functional groups of the drug molecules linked to the active sites (Ca鈥揙H and Si鈥揙H groups) of MS-CSH on the surface by electrostatic interactions. In addition, it is found that the stoichiometric ratio of Ca²⁺ ions of CSH carriers and the functional groups of drug molecules may significantly influence the DLCs.